Species: Hu, Mu
Applications: WB, ChIP, ICC/IF, IHC, IP, ChIP, KD
Host: Mouse Monoclonal
Species: Hu
Applications: WB, KD
Host: Rabbit Polyclonal
Species: Mu, Rt
Applications: WB, Flow, ICC/IF
Host: Rabbit Monoclonal
Species: Hu
Applications: AC
Description
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
4152 |
| Alternate Names |
- CXXC-type zinc finger protein 3
- methyl-CpG binding domain protein 1 isoform PCM1
- methyl-CpG binding domain protein 1
- methyl-CpG-binding domain protein 1
- Methyl-CpG-binding protein MBD1
- PCM1CXXC3RFT
- Protein containing methyl-CpG-binding domain 1
- the regulator of fibroblast growth factor 2 (FGF-2) transcription
|
Research Areas for MBD1
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Chromatin Research
