MafA Products

Description

Insulin gene expression is regulated by several islet-enriched transcription factors. However, MafA is the only beta cell-specific activator. MafA selectively induces endogenous insulin transcription in non-beta cells. MafA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MafA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.

Bioinformatics

Entrez	378435 Mouse 389692 Human
Uniprot	NP_919331.1 Mouse NP_963883 Human Q8CF90 Mouse
Product By Gene ID	389692
Alternate Names	hMafA Pancreatic beta-cell-specific transcriptional activator RIPE3b1 RIPE3B1 transcription factor MafA Transcription factor RIPE3b1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) V-maf musculoaponeurotic fibrosarcoma oncogene homolog A

Research Areas for MafA

Find related products by research area and learn more about each of the different research areas below.

Diabetes Research
Lipid and Metabolism
Transcription Factors and Regulators