LIM Kinase 1/2 Products

Description

Proteins containing LIM motifs are typically involved in cell fate determination and growth control. A family of proteins designated LIM kinases, including LIMK-1 and LIMK-2, has been identified. LIMK-1 has been shown to regulate the stabilization of F-Actin structures and cofilin activity, indicating that LIMK-1 plays a role in a signaling pathway involved in the regulation of cell motility and morphogenesis. LIMK-1 inhibits neuronal differentiation of PC12 cells, and is thought to act by interfering with events downstream of MAPK activation. Expression patterns of LIMK-1 and LIMK-2 suggest that these proteins may have different functions during development. A truncated form of LIMK-2 has been identified in adult testis that is thought to arise from an alternative initiation exon.

Bioinformatics

Entrez	3984 Human 3985 Human 65172 Rat
Uniprot	P53667 Human
Product By Gene ID	3984
Alternate Names	EC 2.7.11.1 LIM domain kinase 1 LIM motif-containing protein kinase LIMKLIMK-1

Research Areas for LIM Kinase 1/2

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
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Phospho-Specific
Protein Kinase