Kv1.1 Products

Description

Kv1.1 belongs to a (Shaker) subfamily of the pota ium channel family. It is a major constituent of presynaptic A-type channels that modulate synaptic transmi ion in CNS neurons. Kv1.1-containing channels have been shown to be complexed with Lgi1, which is causative for an autosomal dominant form of lateral temporal lobe epilepsy. In the hippocampus Kv1.1 and Lgi1 are coa embled with Kv1.4 and Kv 1 in axonal terminals. Kv1.1 is an abundant Kv subunit in the brain that is found predominantly localized to axons and nerve terminals. Mutations in human Kv1.1 result in the dominant disorder Episodic Ataxia Type 1.

Bioinformatics

Entrez	24520 Rat 3736 Human
Uniprot	NM_000217 Human NP_000208 Human NP_000208.2 Human P10499 Rat Q09470 Human
Product By Gene ID	3736
Alternate Names	AEMK EA1 HBK1 HUK1 Kv1.1 KV1.1 MBK1 MGC126782 MGC138385 MK1 potassium voltage-gated channel subfamily A member 1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodicataxia with myokymia) RBK1 Voltage-gated K(+) channel HuKI Voltage-gated potassium channel HBK1 Voltage-gated potassium channel subunit Kv1.1