Species: Hu
Applications: WB, ELISA, IP
Host: Mouse Monoclonal
Species: Hu
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
KMT3B / NSD1 encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorac domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
64324 |
| Alternate Names |
- Androgen receptor coactivator 267 kDa protein
- Androgen receptor-associated protein of 267 kDa
- ARA267STO
- DKFZp666C163
- EC 2.1.1.43
- FLJ10684
- FLJ22263
- FLJ44628
- H3 lysine-36 and H4 lysine-20 specific
- KMT3BSotos syndrome
- Lysine N-methyltransferase 3B
- NR-binding SET domain-containing protein
- nuclear receptor binding SET domain protein 1
|
