JNK2 Products

Description

JNK protein kinases are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group includes the 46-kDa isoform JNK1 and the 55-kDa protein kinase JNK2. The activities of both JNK isoforms are markedly increased by exposure of cells to UV radiation (1). JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 (2). JNK2 functions in a cell-type-specific and stimulus-dependent manner, being required for apoptosis of immature thymocytes induced by anti-CD3 antibody but not for apoptosis induced by anti-Fas antibody, UVC or dexamethasone. JNK2 is not required for activation-induced cell death of mature T cells (3).

Bioinformatics

Entrez	26420 Mouse 50658 Rat 5601 Human
Uniprot	AAH32539 Human MK09_HUMAN Human NM_002752 Human NM_139068 Human NP_001128516 Human NP_002743.3 Human NP_620708 Human NP_620709 Human P45984 Human
Product By Gene ID	5601
Alternate Names	c-Jun kinase 2 c-Jun N-terminal kinase 2 EC 2.7.11 EC 2.7.11.24 JNK2A JNK2BETA JNK2JNK2ALPHA JNK-55 Jun kinase MAP kinase 9 MAPK 9 mitogen-activated protein kinase 9 p54a p54aSAPK PRKM9JNK2B SAPK Stress-activated protein kinase JNK2

Research Areas for JNK2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Immunology
Innate Immunity
Phospho-Specific
Protein Kinase
Signal Transduction
Wnt Signaling Pathway