ITCH/AIP4 Products

Description

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.

Bioinformatics

Entrez	16396 Mouse 311567 Rat 83737 Human
Uniprot	AAH11571.1 Human NM_031483 Human NP_113671 Human NP_113671.3 Human Q96J02 Human Q9BY75 Human
Product By Gene ID	83737
Alternate Names	AIF4 AIP4dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)) atrophin-1 interacting protein 4 Atrophin-1-interacting protein 4 dJ468O1.1 EC 6.3.2 EC 6.3.2.- Itch itchy (mouse homolog) E3 ubiquitin protein ligase itchy E3 ubiquitin protein ligase homolog (mouse) itchy homolog E3 ubiquitin protein ligase NAPP1E3 ubiquitin-protein ligase Itchy homolog NFE2-associated polypeptide 1 ubiquitin protein ligase ITCH