HSF2 Products

Description

Heat shock factor 1 (HSF1) is a heat shock transcription factor that activates the transcription of genes encoding products required for protein folding, processing, targeting, degradation, and function. Up-regulation of expression of heat shock proteins in response to stress occurs at the level of transcription through a heat shock element and a HSF transcription factor. Amino acid sequences for most HSFs are highly conserved. A DNA binding domain is at the N-terminus, hydrophobic repeats (essential to the formation of active trimers) are adjacent to this binding domain, and another short hydrophobic repeat (necessary for suppression of trimerization) occurs toward the C-terminus. HSF2 exists as two isoforms, the alpha form being more transcriptionally active than the smaller beta form. Various experiments have suggested that HSF2 may play roles in differentiation and development.

Bioinformatics

Entrez	15500 Mouse 3298 Human 64441 Rat
Uniprot	AAH05329 Human AAI21051 Human NM_004506 Human Q03933 Human
Product By Gene ID	3298
Alternate Names	heat shock factor 2 heat shock factor protein 2 heat shock transcription factor 2MGC75048 HSF 2 HSTF 2 HSTF2 MGC117376 MGC156196