HFE Products

Description

HFE is encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

Bioinformatics

Entrez	3077 Human
Uniprot	NP_000401 Human NP_000401.1 Human Q30201 Human Q30201-4 Human
Product By Gene ID	3077
Alternate Names	dJ221C16.10.1 hemochromatosis hereditary hemochromatosis protein HLA-H hereditary hemochromatosis protein HH high Fe HLAH HLA-HHFE1 MGC103790 MHC class I-like protein HFE MVCD7

Related HFE Blog Posts

Check out the latest blog posts on HFE.

The role of Smoothened in pulmonary pathologies The Hedgehog (Hh) family of secreted proteins is involved in a number of developmental processes, one of which is the development of cancer. Past data suggests that the Sonic hedgehog (Shh) receptor is composed of two transmembrane proteins, Patche...    Read more.

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