GALNT6 Products

Description

GALNT6 encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.

Bioinformatics

Entrez	11226 Human
Uniprot	NM_007210 Human NP_009141 Human NP_009141.2 Human Q8NCL4 Human
Product By Gene ID	11226
Alternate Names	EC 2.4.1.41 GalNAc transferase 6 GalNAcT6 GALNAC-T6 GalNAc-T6 Polypeptide GalNAc transferase 6 polypeptide N-acetylgalactosaminyltransferase 6 pp-GaNTase 6 Protein-UDP acetylgalactosaminyltransferase 6 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6 UDP-N-acetyl-alpha-D-galactosamine: polypeptideN-acetylgalactosaminyltransferase 6 UDP-N-acetyl-alpha-D-galactosamine:polypeptideN-acetylgalactosaminyltransferase 6 (GalNAc-T6)