Species: Hu
Applications: WB, Simple Western, B/N
Host: Goat Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC, KO
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, Flow, ICC/IF
Host: Rabbit Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Bioactivity
Species: Mu
Applications: Bioactivity
Species: Hu
Applications: AC
Description
SPON1 is a member of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains. The TSRs of SPON1 proteins are typical of class 2 TSRs. SPON1, which is similar to thrombospondin, is a extracellular matrix attached molecule that promotes neurite outgrowth and inhibits angiogenesis. Analysis of gain and loss of function experiments reveal that SPON1 is required for accurate pathfinding of embryonic axons, and plays a dual role in patterning axonal trajectories. It promotes the outgrowth of commissural and inhibits the outgrowth of motor axons, and has also been implicated in inflammatory processes in the nervous system.
Bioinformatics
| Entrez |
Mouse
Human
Rat
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
10418 |
| Alternate Names |
- F-spondin
- f-spondin
- KIAA0762VSGP/F-spondin
- MGC10724
- spondin 1, (f-spondin) extracellular matrix protein
- spondin 1, extracellular matrix protein
- spondin-1
- Vascular smooth muscle cell growth-promoting factor
- VSGP
|
Research Areas for F-Spondin/SPON1
Find related products by research area and learn more about each of the different research areas below.
Neuroscience
![Western Blot F-Spondin/SPON1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/FSpondin_AF3135_Western_Blot_20824.jpg)
![Simple Western F-Spondin/SPON1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/FSpondin_AF3135_Simple_Western_20927.jpg)
