Species: Hu, Mu, Rt, Ha, Rb
Applications: WB, Flow, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Ha
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: ICC/IF
Host: Rabbit Polyclonal
Species: Rt
Applications: ICC/IF, AC
Species: Rt
Applications: AC
Species: Hu
Applications: AC
Description
Iodothyronine deiodinase 3 (DIO3) is a peroxidase enzyme that is involved in the activation or deactivation of thyroid hormones. Specifically, DIO-3 deiodinizes the thyroid hormones T4 and T3 into their respective inactive metabolites, RT3 and T2.
Dio3 has an essential role for regulation of thyroid hormone inactivation during embryological development, and may play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Dio3 has been linked to the development of consumptive hypothyroidism in both infants and adults.
DIO3 antibodies are useful tools for hormone regulation research and in some embryological development studies.
Bioinformatics
| Entrez |
Mouse
Human
Rat
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
1735 |
| Alternate Names |
- 5DIII
- D3
- deiodinase, iodothyronine, type III
- DIOIII
- EC 1.97.1
- EC 1.97.1.11
- ITDI3
- placental type
- thyroxine deiodinase type III (selenoprotein)
- Type 3 DI
- type 3 iodothyronine selenodeiodinase
- type III iodothyronine deiodinase
- type-III 5' deiodinase
- Type-III 5'-deiodinase
|
