DIO3 Antibody Blocking Peptide Summary
Description |
A DIO3 antibody blocking peptide. |
Localization |
Cell membrane; Single-pass type II membrane protein |
Specificity |
This peptide is specific for NB110-96414 only. |
Protein/Peptide Type |
Antibody Blocking Peptide |
Gene |
DIO3 |
Applications/Dilutions
Dilutions |
- Antibody Competition
- Immunocytochemistry/ Immunofluorescence reported in scientific literature (PMID 21828183)
|
Application Notes |
This peptide is useful as a blocking peptide for NB110-96414. For further blocking peptide related protocol, click here. |
Packaging, Storage & Formulations
Storage |
Store at -80C. Avoid freeze-thaw cycles. |
Buffer |
Peptide dissolved in dH2O. Contains no BSA. |
Preservative |
No Preservative |
Concentration |
1.0 mg/ml |
Alternate Names for DIO3 Antibody Blocking Peptide
Background
Dio3, or type 3 iodothyronine deiodinase, can regulate circulating fetal thyroid hormone concentrations throughout gestation. It has an essential role for regulation of thyroid hormone inactivation during embryological development, and may play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Dio3 has been linked to the development of consumptive hypothyroidism in both infants and adults.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are
guaranteed for 3 months from date of receipt.
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Publications for DIO3 Peptide (NB110-96414PEP) (0)
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Product General Protocols
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Video Protocols
FAQs for DIO3 Peptide (NB110-96414PEP). (Showing 1 - 1 of 1 FAQ).
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I am looking for a Dio3 peptide that I can inject in vivo to produce a biological effect. Can you provide information or confirm whether the Dio3 peptide you have would be effective as a biological agent in vivo?
- I have pulled up information on the Dio3 peptides and recombinant proteins that we have available. Unfortunately I would not expect any of them to be biologically active and capable of producing a response when injected in vivo. The two peptides we carry are simply intended to be used for negative control competition assays to block signal of the primary and determine what is specific and non-specific as far as signal is concerned. The other two recombinant proteins are ones we distribute for a Taiwanese company called Abnova and they should not be biologically active based on the cell free wheat germ system employed to synthesize them. We will typically list our active proteins with an indication of such on our datasheet if it has been tested and usually the application of functional listed.
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