COMT Products

Description

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. The transcript variants are formed through the use of alternative translation initiation sites and promoters.

Bioinformatics

Entrez	1312 Human
Uniprot	AAH00419 Human AAH00419.2 Human NM_007310 Human NP_000745 Human NP_000745.1 Human NP_009294.1 Human P21964 Human
Product By Gene ID	1312
Alternate Names	catechol O-methyltransferase catechol-O-methyltransferase EC 2.1.1.6

Research Areas for COMT

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism