Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, Flow, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Description
C3 consists of two polypeptide chains (alpha, molecular weight 115 kDa and beta, molecular weight 75 kDa) and is usually present in serum at 1 to 2 mg/L. It is the pivotal protein of the complement system, being central in the classical pathway and the alternative pathway. It is cleaved by the classical pathway convertase C4b2a and the alternative pathway convertase C3bBb, into C3b and C3a. The C3a peptide is an important anaphylotoxin, whilst the C3b has three main roles: 1. Important opsonin phagocyte cells have C3b receptors. 2. Participates in the amplification loop in the alternative pathway. 3. Complexed with C4b2a this is the C5 convertase which leads ultimately to target cell lysis. C3c, along with iC3b and C3dg, is formed as a result of C3b inactivation by Factor I and various cofactors. The C3 fragments are eliminated by liver phagocytic cells.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
718 |
| Alternate Names |
- AHUS5
- ARMD9
- ASP
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
- complement C3
- complement component 3
- complement component C3
- CPAMD1acylation-stimulating protein cleavage product
|
