CISH/CIS-1 Products

Description

CISH is encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor.

Bioinformatics

Entrez	1154 Human
Uniprot	AAH31590 Human AAH31590.1 Human NM_145071 Human NP_659508 Human NP_659508.1 Human
Product By Gene ID	1154
Alternate Names	CIS-1cytokine-inducible SH2-containing protein CIScytokine-inducible inhibitor of signaling type 1B cytokine inducible SH2-containing protein G18Protein G18 SOCS Suppressor of cytokine signaling

Research Areas for CISH/CIS-1

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction