Catenin alpha 1 Products

Description

Cadherin and catenin compose cell adhesion complex and are indispensable for tight cell-cell adhesion. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, thus possibly contributing to cancer invasion and metastasis (1). At least three proteins (alpha, beta, and gamma catenin) comprise the cytoplasmic domain of the cadherin cell-cell adhesion complex. Data, with the reported structure of other catenin genes, suggest that vinculin and alpha-catenin generate a superfamily of proteins mediating membrane-cytoskeletal associations (2). Presenilin-1 (PS1) overexpression in human kidney cells enhances cell-cell adhesion and data show that PS1 incorporates into the cadherin/catenin adhesion system and regulates cell-cell adhesion. PS1 concentrates at intercellular contacts in epithelial tissue; in brain, it forms complexes with both E- and N-cadherin and concentrates at synaptic adhesions (3).

Bioinformatics

Entrez	12385 Mouse 1495 Human 307505 Rat
Uniprot	AAH31262.1 Human NM_001903 Human NP_001894 Human NP_001894.2 Human P35221 Human
Product By Gene ID	1495
Alternate Names	Alpha E-catenin alpha-catenin alpha-E-catenin alphaE-catenin cadherin-associated protein Cadherin-associated protein CAP102 catenin (cadherin-associated protein), alpha 1 (102kD) catenin (cadherin-associated protein), alpha 1, 102kDa catenin alpha-1 FLJ36832 FLJ52416 Renal carcinoma antigen NY-REN-13

Research Areas for Catenin alpha 1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cellular Markers
Core ESC-Like Genes
Cytoskeleton Markers
Phospho-Specific
Stem Cell Markers