ARHGEF6 Products

Description

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq]

Bioinformatics

Entrez	9459 Human
Uniprot	AAH39856 Human AAH39856.1 Human NP_004831 Human NP_004831.1 Human Q15052 Human
Product By Gene ID	9459
Alternate Names	alphaPIX Alpha-Pix COOL-2 COOL2alpha KIAA0006Cool2 mental retardation, X-linked 46 MRX46 PAK-interacting exchange factor alpha PIXA Rac/Cdc42 guanine exchange factor (GEF) 6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 Rac/Cdc42 guanine nucleotide exchange factor 6 rho guanine nucleotide exchange factor 6

Research Areas for ARHGEF6

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Apoptosis