Als2 Products

Description

Defects in ALS2, or Alsin, are the cause of amyotrophic lateral sclerosis 2 (ALS2), juvenile primary lateral sclerosis (JPLS), and infantile-onset ascending spastic paralysis (IAHSP). ALS2 is a neurodegenerative disorder which is closely related to but clinically distinct from juvenile primary lateral sclerosis. It is a progressive paralytic disorder which results from dysfunction of the motor systems comprising the upper motor neurons of the motor cortex and lower motor neurons of the brain stem and spinal cord. JPLS is a neurodegenerative disorder which is closely related to but clinically distinct from amyotrophic lateral sclerosis. It is a progressive paralytic disorder which results from dysfunction of the upper motor neurons of the motor cortex while the lower neurons are unaffected. IAHSP is characterized by progressive spasticity and weakness of limbs.

Bioinformatics

Entrez	363235 Rat 57679 Human
Uniprot	AAH29174 Human AAH71576.1 Human NP_065970.2 Human P0C5Y8 Rat Q96Q42 Human
Product By Gene ID	57679
Alternate Names	ALS2CR6 alsin ALSJ amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 6 amyotrophic lateral sclerosis 2 (juvenile) Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein Amyotrophic lateral sclerosis 2 protein FLJ31851 IAHSP KIAA1563 MGC87187 PLSJ

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Amyotrophic Lateral Sclerosis Infographic Amyotrophic lateral sclerosis is a neurological disease which impacts motor neurons that are involved in muscle movement throughout the body. The progressive degeneration of neurons causes weakened muscles and can lead to paralysis. There is no cure f...    Read more.

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