AKR1B1 Products

Description

Aldose reductase (also designated AKR1B1, ALDR1, ALR2 or AR) is member of the monomeric NADPH-dependent aldoketoreductase family. Aldose reductase, which has a molecular mass of 36 kDa, catalyzes the reduction of various aldehydes and has been implicated in the development of diabetic complications by catalyzing the reduction of the aldehyde form of glucose, to the corresponding sugar alcohol, sorbitol. This pathway plays a minor role in glucose metabolism in most tissues, however in diabetic hyperglycemia, cells undergoing insulin-independent uptake of glucose accumulate significant quantities of sorbitol. The resulting hyperosmotic stress to cells may be a cause of diabetic complications such as neuropathy, retinopathy, and cataracts. Aldose reductase is very similar to human aldehyde reductase, bovine prostaglandin F synthase and to the European common frog protein, rho-crystallin.

Bioinformatics

Entrez	11677 Mouse 231 Human 24192 Rat
Uniprot	AAH00260 Human AAH00260.1 Human AAH10391 Human NP_001619 Human NP_001619.1 Human P15121 Human
Product By Gene ID	231
Alternate Names	ADR Aldehyde reductase Aldo-keto reductase family 1 member B1 aldo-keto reductase family 1, member B1 (aldose reductase) ALDR1aldose reductase ALR2 ARaldehyde reductase 1 EC 1.1.1 EC 1.1.1.21 Lii5-2 CTCL tumor antigen low Km aldose reductase MGC1804

Research Areas for AKR1B1

Find related products by research area and learn more about each of the different research areas below.

Stem Cell Markers