Catalase Products

Description

Human catalase is an heme-containing peroxisomal enzyme that breaks down hydrogen peroxide to water and oxygen; it is implicated in ethanol metabolism, inflammation, apoptosis, aging and cancer. The 1.5A resolution human enzyme structure, both with and without bound NADPH, establishes the conserved features of mammalian catalase fold and assembly, implicates Tyr370 as the tyrosine radical, suggests the structural basis for redox-sensitive binding of cognate mRNA via the catalase NADPH binding site, and identifies an unexpectedly substantial number of water-mediated domain contacts (1). Because catalase has a low affinity for H2O2, it has been suggested that glutathione peroxidase clears most H2O2 within the erthrocyte and that catalase is of little import. It has been hypothesized that erythrocyte catalase might function to protect heterologous somatic cells against challenge by high levels of exogenous H2O2 (e.g., in areas of inflamation) (2).

Bioinformatics

Entrez	12359 Mouse 24248 Rat 531682 Bovine 847 Human
Uniprot	NM_001752 Human NP_001743 Human NP_001743.1 Human P00432 Bovine P04040 Human
Product By Gene ID	847
Alternate Names	catalase EC 1.11.1.6 MGC138422 MGC138424

Research Areas for Catalase

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cellular Markers
Hypoxia
Lipid and Metabolism
Neuroscience
Peroxisome Markers
Signal Transduction