BRD4 Products

Description

BRD4 is encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq]

Bioinformatics

Entrez	23476 Human 362844 Rat 57261 Mouse
Uniprot	AAH35266.1 Human NP_055114 Human NP_490597 Human O60885 Human
Product By Gene ID	23476
Alternate Names	bromodomain containing 4 bromodomain-containing 4 CAPchromosome-associated protein HUNK1bromodomain-containing protein 4 HUNKI MCAP Protein HUNK1

Related BRD4 Blog Posts

Check out the latest blog posts on BRD4.

Understanding the relationship between NUT and BET proteins in NMC NUT has been found to fuse with bromodomain-containing proteins 3 and 4 (BRD3 and BRD4) in NUT midline carcinoma (NMC), a very rare, extremely aggressive, and genetically defined human cancer. NMC has recently been designated as a sub classificati...    Read more.

Epigenetic Control of Autophagy By Christina Towers, PhD. In the last 20 years, epigenetic regulation has become front and center for almost all fields of biology and its role in diseases like cancer and neurodegeneration are being heavily studi...    Read more.

NUT - A Protein Coding Gene The NUT gene is found on chromosome 15q14 and encodes for the NUT protein which is a key component of the RNA polymerase II Mediator complex. This multi-subunit assembly is required for all RNA pol II-dependent transcriptional activation, coordinating...    Read more.

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