ATG4A Products

Description

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.; FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.; ENZYME REGULATION: Inhibited by N-ethylmaleimide; SUBCELLULAR LOCATION: Cytoplasm;

Bioinformatics

Entrez	115201 Human 666468 Mouse
Uniprot	NP_443168 Human NP_443168.2 Human Q8WYN0 Human
Product By Gene ID	115201
Alternate Names	APG4 autophagy 4 homolog A (S. cerevisiae) APG4A ATG4 autophagy related 4 homolog A (S. cerevisiae) AUTL2 AUT-like 2 cysteine endopeptidase AUT-like 2, cysteine endopeptidase (S. cerevisiae) autophagin 2 Autophagin-2 autophagin-2 cysteine endopeptidase cysteine protease ATG4A EC 3.4.22 EC 3.4.22.- hAPG4A

Research Areas for ATG4A

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Autophagy
Phospho-Specific

Related ATG4A Blog Posts

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ATG4A - protease that initiates ATG8 lipidation during autophagosome elongation There are 3 major autophagy pathways- microautophagy, chaperone-mediated autophagy, and macroautophagy. Macroautophagy is the pathway herein referred to as simply autophagy. Autophagy can be broken down into 4 main stages: phagophore nucleatio...    Read more.

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