SOX9 is a member of the SOX family of HMG DNA-binding domain transcription factors. The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. cAMP and protein kinase A (PKA) stimulation appear to induce SOX-9 nuclear translocation through its nuclear import upon phosphorylation at two particular serine residues. It is required for the development and differentiation of multiple cell lineages and is expressed in primary and recurrent prostate cancers.
