HIF1-alpha

Transcription factor EB (TFEB) is a member of the MiTF/TFE (Microphthalmia/TFE) subfamily of basic/helix-loop-helix/leucine zipper transcription factors. This group of proteins is involved in the proliferation and development of specific cell types such as osteoclasts or melanocytes. Recently scientists have begun to uncover the roles of MiTF/TFE proteins in organelle biogenesis and energy metabolism (1). TFEB, for example, is a known regulator of lysosome biogenesis.

The heat shock protein 70 (Hsp70) family are a group of chaperones involved in various cellular processes including protein folding and protein degradation. In addition to maintaining normal cellular homeostasis by processing newly synthesized protein, the Hsp70 family is also important in controlling intracellular signaling pathways by regulating the folding and activity of signaling proteins. The various groups within the Hsp70 family are characterized by their expression levels, activities, and subcellular localization (1).