Is has been established that the regulatory transcription factor FOXP3 (a member of the forkhead/winged-helix family of transcription factors) is imperative to immune system homeostasis through CD4+CD25+ regulatory T cell function. Distinctively, FOXP3 binds to specific regions of DNA to modulate the activity of genes that are involved in regulating the immune system. Interruption of FOXP3 activity leads to autoimmune disorder, due to Treg cells not having their full ability to act as an immune system balancer.