Notch1 is a member of the Notch family of Type 1 single-pass transmembrane proteins that share an extracellular domain of multiple epidermal growth factor-like (EGF) repeats. Notch family members play key roles in a variety of developmental processes via the regulation of cell fate. These processes include cell-fate determination, proliferation, and cell contact-dependent signaling. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes a key development intercellular signaling pathway.
