Autophagy is an important cellular process that maintains homeostasis by degrading and recycling damaged proteins and organelles. Autophagy receptors, such as p62/SQSTM1, recognize these intracellular cargo and mediate their engulfment by the double-membrane autophagosome. The autophagosomes are subsequently targeted to the lysosome for degradation. An early regulatory step in this process is the activation and lipidation of ATG8 related proteins such as microtubule-associated protein-1 light chain 3 (LC3).
