TRPV1 (transient receptor potential cation channel subfamily vanilloid member type 1) is a polymodal nociceptor that is commonly expressed in peripheral nerve endings and dorsal root ganglia. It is activated by heat, low pH, vanilloids, capsaicin, and other noxious stimuli and is involved in the transmission and modulation of pain. Not surprisingly, TRPV1 is directly related to hyperalgesia—increased sensitivity to pain—as hyperalgesia is significantly reduced when TRPV1 is genetically eliminated or pharmacologically blocked.
