RANK antibody

Apoptosis, or programmed cell death, is a normal component of cellular differentiation and the development of multicellular organisms. Receptor activator of NF-kB (RANK) lacks significant homology with the other family members of the tumor necrosis factor receptor (TNFR) superfamily. The cytoplasmic domain of RANK interacts with the tumor necrosis factor receptor associated factors, adaptor proteins such as TRAF2, TRAF5 and TRAF6.

RANKL is the ligand for the receptor activator of NFkB (RANK) that belongs to the tumor necrosis factor receptor (TNFR) superfamily. RANK overexpression induces the NFkB and c-Jun-terminal kinase (JNK) downstream pathways. This pathway has been studied in detail in the bone remodeling system with regards to osteoclast activity and induction.