The neurodegenerative disorder, Alzheimer's disease, is responsible for 60 to 80% of all dementia cases.1 Neurodegeneration occurs in response to the accumulation of amyloid-β plaques and neurofibrillary tangles composed of hyperphosphorylated tau.
Ubiquitin is an abundant and essential cellular 9-kd protein that is conserved across evolution from yeast to humans. Ubiquitin is used by cells as a covalent modifier of other proteins both to activate their function and to target them for degradation, depending on the degree of ubiquitination.
