LYVE1 (lymphatic vessel endothelial hyaluronan receptor-1) is one of the most specific and widely used mammalian lymphatic endothelial markers.It is found in lymph nodes and at the luminal/abluminal surfaces of lymphatic vessels. It is a single-pass type I membrane protein that exists in a disulfide-linked homodimer form. LYVE1 undergoes ligand-dependent internalization and recycling at the cell surface, and exhibits ligand-specific transporter trafficking between intracellular organelles and the plasma membrane.
