glioma

Nur77 is a member of the steroid/thyroid hormone phosphoprotein receptor superfamily. It is heavily post-translationally modified and rapidly induced in response to androgens and growth factors. It governs fundamental processes such as cell proliferation, differentiation, and apoptosis. For some time, it was classified as an orphan receptor with no identifiable or known ligand, but scientists finally were able to identify a novel class of methylene-substituted diindolylmethanes (C-DIM) as its endogenous ligand.

The p14ARF (Alternative Reading Frame) tumor suppressor is a protein product of the alternative reading frame (ARF) of the human INK4a locus which regulates a series of cell cycle regulatory proteins to promote cell cycle arrest in response to abnormal hyper-proliferative growth stimuli. p14ARF alterations are common in human cancers and, when inherited, confer susceptibility to cutaneous melanoma (1).