CD3 antibody

Microglia are the resident macrophages of the central nervous system, and the first line of immune defense. Pioneering antibody research in the 1990's identified the Integrin beta 2 protein (also called ITGB2, complement receptor 3, CR3, CD18, and Mac-1) as one of the key proteins in the recruitment of microglial cells. The ITGB2 subunit A is commonly called CD11b, and antibodies to this subunit are widely used as microglial markers.

CD4 is a member of the cluster of differentiation family of proteins, mainly expressed on the surface of thymocytes and a specific subset of mature T-cells. CD4 antibody studies have also shown it expressed on monocytes, cortical cells, microglial cells, dendritic cells and macrophages. The CD4 antibody is widely used in cell marker studies, CD4 being one of the most common CD markers in use.