Arthritis

Matrix metalloproteinases (MMPs) are responsible for the degradation of extracellular matrix proteins. MMPs are essential for tissue remodeling during normal processes such as embryonic development as well as pathological conditions such as arthritis and tumor metastasis. MMP3, a member of the stromelysin family, has broad specificity for proteins such as collagens, fibronectin, proteoglycans, and elastin making it an important player in extracellular matrix remodeling. These activities are especially important during tumorigenesis by enhancing epithelial to mesenchymal transition.

Over the years muscular dystrophies have become a popular area of research. These are a group of inherited disorders that involve an increase in muscle weakness over time. These disorders greatly decrease the quality of life and there are no known cures. Research in this area appears to have excelled in the past two years with findings related to the genes NCoR and EZH2.

S100A12 (Calgranulin C) belongs to the S100 family of calcium-binding proteins. The 20 members of this group share EF-hand domains which are involved in binding of calcium. S100A12 is expressed by granulocytes, whereas its expression by monocytes remains controversial (1). S100A12 is secreted by activated granulocytes (2). S100A12 is a ligand for the receptor for advanced glycation end products (RAGE) expressed on macrophages, lymphocytes and endothelium.

MMP2 antibodies have proven to be important tools for cancer research and extracellular matrix studies. Novus Biologicals offers an excellent MMP2 antibody (Catalog Number NB200-114) for Western blot, immunoprecipitation, ELISA, and immunohistochemical/immunofluorescence staining in human, mouse and rat samples. Originally developed in 2005, this MMP-2 clone (8B4) has been thoroughly characterized and cited in a growing number of published journal articles.