Interleukin 6 is a complex pleiotropic cytokine having both anti and pro-inflammatory effects. Alterations in expression contribute to many human diseases, and the IL6 antibody is widely used in the research areas of innate and adaptive immunity, autoimmune disorders; CAD (coronary artery disease); neurological disorders; cancer and inflammatory disease. We at Novus Biologicals are one of the leading antibody suppliers for interleukin research.
IL6 is secreted by a variety of cells including macrophages, monocytes, T-cells, fibroblasts, endothelial cells, and keratinocytes, in response to LPS, TNF alpha, PDGF and other stimulants. It has a diverse number of roles, including immunity, the inflammatory response, hematopoiesis, and B-cell and nerve cell differentiation.
IL6 plays an important role in fever development, mediating the production of acute phase reactants in hepatocytes, and increasing body temperature through its action on the hypothalamus, skeletal muscle and adipose tissue. IL6 antibody studies have shown the protein is overexpressed in a number of cancers, as well as diabetes, depression, atherosclerosis, lupus, Alzheimer's, rheumatoid arthritis and other autoimmune and inflammatory diseases. Recent IL6 antibody research has focused on developing anti- IL6 therapies against some of these conditions; an anti-IL6 RA therapy has now been approved for clinical use, and a number of groups are working on IL6 antagonists targeting cancer.
Antibody suppliers now offer colorimetric and ELISA kits to aid IL6 antibody research. Our sandwich ELISA kits offer the highest level of sensitivity, using a convenient 96-well strip format to minimize waste. Our kit includes everything you need for accurate, reproducible assays; including buffers, standard solutions, IL6 antibody reagents and substrate.
Novus Biologicals offers IL6 reagents for your research needs including:
