FOXO1 belongs to the very large Forkhead family of transcription factors which contain a conserved distinct DNA-binding domain known as the Forkhead Box, or FOX. The Forkhead domain is a 100 amino acid long motif capable of binding and bending DNA, and is also known as a “winged helix”. Forkhead family members are involved in a very diverse and wide range of physiological processes from cell cycle, apoptosis, and oxidative-stress resistance. The “O” class of proteins in particular are all regulated by the insulin/PI3K/AKT pathway.
