Rad50 Products

Description

Rad50 is a 153kDa protein that associates with Mre11 and p95 (Nibrin) to form a multiprotein complex involved in the double strand break repair process. Upon DNA damage, the complex translocates to the nucleus of damaged cells, binds DNA, and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. Overall, Rad50 is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination.

Bioinformatics

Entrez	10111 Human 19360 Mouse 64012 Rat
Uniprot	NM_005732 Human NP_005723.2 Human Q92878 Human
Product By Gene ID	10111
Alternate Names	DNA repair protein RAD50 EC 3.6 EC 3.6.1.15 EC 3.6.3 EC 3.6.3.27 hRAD50 hRad50 NBSLD RAD50 (S. cerevisiae) homolog RAD50 homolog (S. cerevisiae) RAD502 RAD50-2

Research Areas for Rad50

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
Checkpoint signaling
Chromatin Research
DNA Double Strand Break Repair
DNA Repair
Homologous Recombination
Non-homologous end-joining

Related Rad50 Blog Posts

Check out the latest blog posts on Rad50.

The MRE11 Complex and DNA Damage Response The maintenance of genome stability depends on the DNA damage response (DDR) which is a complex signaling network including cell cycle checkpoints, DNA repair and damage tolerance pathways. The DDR complex has the ability to sense DNA damage and tra...    Read more.

RAD50 and DNA Damage Response DNA repair protein RAD50 is a component of the MRN complex (Mre11-RAD50-Nbs1) responsible for DNA double strand break (DSB) repair. DSBs are caused by ionizing radiation, certain chemotherapy drugs, metabolic reactive oxygen species (ROS), replication...    Read more.

Read more Rad50 related blogs.