Recombinant Human VIPR2 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Vasoactive intestinal polypeptide receptor 2 (VIPR2 or VPAC2) is a transmembrane receptor that belongs to the B class G protein coupled receptor family of proteins (1). Mature, human VIPR2 consists of an extracellular domain (ECD) with a hormone receptor region followed by seven transmembrane regions and a short cytoplasmic domain. The ECD of human VIPR2 shares 90% amino acid sequence identity with both mouse and rat VIPR2. Human VIPR2 is expressed predominantly in skeletal muscle, and to a lesser extent in the brain, heart, pancreas, and placenta (1). VIPR2 is coupled to a cAMP mediated signal transduction pathway and binds two homologous neuropeptides, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP), with high affinity (1). VIP plays several roles during neural development, including stimulating neurogenesis, promoting survival of neurons, and assisting in neuron repair (1, 2). Additionally, VIP signaling via VIPR2 has been implicated in regulating immune responses (3). VIPR2 gene duplication and altered signaling of VIP has been associated with the pathogenesis of schizophrenia and may also play a role in autism (4-6). VIPR2 activation has been linked to disruption of cortical neuronal maturation in mice (7). Studies suggest that VIPR2 could be a potential target in the development of novel antipsychotic drugs (5).

Array 11003-VR

• VIPR2/VPAC2 Antibodies
• VIPR2/VPAC2 Lysate
• VIPR2/VPAC2 Protein
• VIPR2/VPAC2 Proteins and Enzyme