Lambda Light Chain Antibody [Biotin]

All five immunoglobulin classes share the same basic four polypeptide chain structure of two heavy-chains and two light chains. There are five heavy chain types, and two light-chain types (Kappa and Lambda) both having a molecular weight of 22.5kDa. Any heavy-chain type can associate with either light-chain type, but on any immunoglobulin molecule both light-chains are of the same type. Kappa and Lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of Kappa to Lambda is 70:30 , the vast majority of which is bound to heavy-chain in immunoglobulin. In normal individuals low levels of free light-chain arepresent in serum (kappa, 1.6-15.2 mg/L; Lambda, 0.4-4.2mg/L), with the occurrence of multiple myeloma or other B-cell malignancies these levels can be greatly elevated and can be found at high levels in the urine (Bence-Jones proteins).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: FLOW.

Showing Publication 1 - 1 of 1.

Publication using NB100-62142	Applications	Species
Schwaigerlehner L, Mayrhofer P, Diem M et al Germinality does not necessarily define mAb expression and thermal stability. Appl Microbiol Biotechnol. 2019-09-01 [PMID: 31350616] (FLOW, Human) Details: Citation using the Biotin version of this antibody.	FLOW	Human

Array NB100-62142

• Lambda Light Chain Antibodies
• Lambda Light Chain ELISA Kit
• Lambda Light Chain Antibodies