Rabbit IgG Isotype Control [Alexa Fluor® 488]

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

IgG is a monomeric immunoglobulin, built of two heavy chains gamma and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins in humans. This is the only isotype that can pass through the human placenta, thereby providing protection to the fetus in its first weeks of life before its own immune system has developed. It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Isotype Controls are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Flow Cytometry, Flow-CS, ICC/IF.

Showing Publications 1 - 6 of 6.

Publications using NBP2-24982	Applications	Species
Montes de Oca R, Alavi AS, Vitali N et al. Belantamab Mafodotin (GSK2857916) Drives Immunogenic Cell Death and Immune-mediated Antitumor Responses In Vivo Molecular Cancer Therapeutics 2021-10-01 [PMID: 34253590] (Flow Cytometry)	Flow Cytometry
Takanashi Naoya, Tomosada Yohsuke, Villena Julio et al. Advanced application of bovine intestinal epithelial cell line for evaluating regulatory effect of lactobacilli against heat-killed enterotoxigenic Escherichia coli-mediated inflammation. BMC Microbiol. [PMID: 23497067] (ICC/IF) Details: Citation using the Alexa Fluor 488 form of this antibody.	ICC/IF
Turco F, Sarnelli G, Cirillo C et al. Enteroglial-derived S100B protein integrates bacteria-induced Toll-like receptor signalling in human enteric glial cells. Gut. [PMID: 23292665] (ICC/IF, Human) Details: Citation using the Alexa Fluor 488 form of this antibody.	ICC/IF	Human
Shimazu T, Villena J, Tohno M et al. Immunobiotic Lactobacillus jensenii elicits anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the Toll-like receptor signaling pathway. Infect Immun. 2012-01-01 [PMID: 22083706] (Flow-CS) Details: Cat no 20304E (normal rabbit IgG isotype control): Flow (cell surface), Fig 4C (porcine intestinal epitheliocyte cell line).	Flow-CS
Wu J, Meng Z, Jiang M et al. Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific. Immunology. [PMID: 19922426] Details: Citation using the PE/Cy5 form of this antibody.
Patole PS, Pawar RD, Lech M et al. Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice. Nephrol Dial Transplant. 2006-11-01 [PMID: 16954173] Details: For IHC (frozen) on mouse kidney sections (Fig. 5): TLR3 (IMG-516), TLR7 (IMG-581A), TLR9 (IMG-431) and Rabbit IgG isotype control antibody (20304). For Flow (Intacellular) and Flow (Cell surface) on J774 mouse macrophage-like cell line (Fig 6B): TLR7 (IMG-581A), TLR9 (IMG-431) and Rabbit IG isotype control antibody (20304).

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer			02/01/2018	View Summary Lot B6112117AF488 Comments Comments This antibody served as a negative control for ICC staining.

Array NBP2-24982

• IgG Antibodies
• IgG ELISA Kits
• IgG Isotype Controls
• IgG Kit
• IgG Proteins
• IgG Antibodies
• IgG ELISAs