Goat anti-Rat IgA Heavy Chain Secondary Antibody Summary
| Immunogen |
Rat IgA |
| Specificity |
By immunoelectrophoresis and ELISA this reacts specifically with rat IgA. This may cross react with IgA from other species |
| Isotype |
IgG |
| Clonality |
Polyclonal |
| Host |
Goat |
| Purity |
Immunogen affinity purified |
Applications/Dilutions
| Dilutions |
- ELISA 1:1000 - 1:30000
- Immunocytochemistry/ Immunofluorescence 1:200 - 1:2000
- Immunohistochemistry 1:200 - 1:2000
- Immunohistochemistry-Paraffin 1:200 - 1:2000
- Western Blot 1:1000-1:30000
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze. |
| Buffer |
Phosphate Buffered Saline (PBS) |
| Preservative |
0.09% Sodium Azide |
| Concentration |
1.0 mg/ml |
| Purity |
Immunogen affinity purified |
Background
Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Secondary Antibodies are
guaranteed for 1 year from date of receipt.
Publications for IgA Antibody (NB7107)(5)
Showing Publications 1 -
5 of 5.
| Publications using NB7107 |
Applications |
Species |
| Wang G, Pan L, Zhang Y et al. Intranasal Delivery of Cationic PLGA Nano/Microparticles- Loaded FMDV DNA Vaccine Encoding IL-6 Elicited Protective Immunity against FMDV Challenge. PLoS ONE 20116(11). [PMID: 22110686] |
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Novotny LA, Clements JD, Bakaletz LO et al. Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae. Mucosal Immunol. [PMID: 21326197]
Details:
Citation using the HRP form of this antibody. |
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Huang J, Garmise RJ, Crowder TM et al. A novel dry powder influenza vaccine and intranasal delivery technology: induction of systemic and mucosal immune responses in rats. Vaccine. [PMID: 15542204]
Details:
Citation using the HRP form of this antibody. |
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| Bondy G, Curran I, Doucet J et al. Toxicity of trans-nonachlor to Sprague-Dawley rats in a 90-day feeding study. Food Chem Toxicol 2004-06-01 [PMID: 15110111] |
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| Marquez MG, Sosa GA, Roux ME et al. Developmental study of immunocompetent cells in the bronchus-associated lymphoid tissue (BALT) from Wistar rats. Dev Comp Immunol 2000-09-01 [PMID: 10831802] |
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Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
Video Protocols
FAQs for IgA Antibody (NB7107). (Showing 1 - 1 of 1 FAQs).
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I would like to know if Rat IgA Antibody (NB7107) can be applied in IF for tissue sections? What's the difference between IF/ICC and IF?
- Our rat IgA antibody with catalogue number NB7107 is covered by our 100% guarantee for immunohistochemistry with paraffin-embedded rat samples, irrespective of whether you use a fluorescent detection method or DAB staining. ICC/IF stands for immunocytochemistry / immunofluorescence, and refers to the staining of cells. IHC stands for immunohistochemistry and refers to the staining of tissues. IHC-P indicates that the antibody has been validated with paraffin-embedded samples. NB7107 has not yet been tested for IHC with frozen tissue, which would be listed as IHC-Fr.
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