Human IGFBP-2 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. ALS increases the half-life of IGF/IGFBP complexes in circulation.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 7 of 7.

Publications using DGB200	Applications	Species
Alrashid, MH;Al-Serri, AE;Hussain, RF;Al-Bustan, SA;Al-Barrak, J; Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients Biomedicines 2023-11-28 [PMID: 38137390] (Human)		Human
Alicea, GM;Portuallo, ME;Patel, P;Fane, ME;Carey, AE;Speicher, D;Tang, HY;Kossenkov, AV;Rebecca, VW;Wirtz, DG;Weeraratna, AT; Age-related increases in IGFBP2 increase melanoma cell invasion and lipid synthesis bioRxiv : the preprint server for biology 2023-05-02 [PMID: 37205503] (Human)		Human
M Shimizu, YI Koma, H Sakamoto, S Tsukamoto, Y Kitamura, S Urakami, K Tanigawa, T Kodama, N Higashino, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki Metallothionein 2A Expression in Cancer-Associated Fibroblasts and Cancer Cells Promotes Esophageal Squamous Cell Carcinoma Progression Cancers, 2021-09-10;13(18):. 2021-09-10 [PMID: 34572779] (Human)		Human
P Fahlbusch, B Knebel, T Hörbelt, DM Barbosa, A Nikolic, S Jacob, H Al-Hasani, F Van de Vel, Y Van Nieuwe, D Müller-Wie, B Lapauw, DM Ouwens, J Kotzka Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men Int J Mol Sci, 2020-06-10;21(11):. 2020-06-10 [PMID: 32532003] (Human)		Human
S Sakimoto, V Marchetti, E Aguilar, K Lee, Y Usui, S Murinello, F Bucher, JK Trombley, R Fallon, R Wagey, C Peters, EL Scheppke, PD Westenskow, M Friedlande CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect JCI Insight, 2017-01-26;2(2):e89906. 2017-01-26 [PMID: 28138561] (Human)		Human
Qibin Zhang Temporal profiles of plasma proteome during childhood development J Proteomics, 2016-11-23;152(0):321-328. 2016-11-23 [PMID: 27890796] (Human)		Human
Kiss K, Baghy K, Spisak S, Szanyi S, Tulassay Z, Zalatnai A, Lohr J, Jesenofsky R, Kovalszky I, Firneisz G Chronic hyperglycemia induces trans-differentiation of human pancreatic stellate cells and enhances the malignant molecular communication with human pancreatic cancer cells. PLoS ONE, 2015-05-26;10(5):e0128059. 2015-05-26 [PMID: 26010611] (Human)		Human

Array DGB200

• IGFBP-2 Antibodies
• IGFBP-2 ELISA Kits
• IGFBP-2 Protein
• IGFBP-2 ELISAs
• IGFBP-2 Proteins and Enzymes