CRLR Antibody (erenumab) [Allophycocyanin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, Func
Clone
erenumab
Clonality
Monoclonal
Host
Human
Conjugate
Allophycocyanin

Order Details

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CRLR Antibody (erenumab) [Allophycocyanin] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
CALCRL / CGRPR
Isotype
IgG2
Clonality
Monoclonal
Host
Human
Gene
CALCRL
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Functional
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Predicted species reactivity: Cynomolgus

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Alternate Names for CRLR Antibody (erenumab) [Allophycocyanin]

  • calcitonin gene-related peptide type 1 receptor
  • calcitonin receptor-like
  • CALCRL
  • CGRP type 1 receptor
  • CGRPR
  • CGRPRCRLRCalcitonin receptor-like receptor
  • CRLR

Background

Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP. The function of CRLR depends on its interaction with RAMP. When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP). In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin. Activation of the receptor leads to an increase in intracellular cyclic AMP. CRLR mediates the vasorelaxation of arteries, suggesting a potential role for the receptor in reaction to injury, particularly in the treatment of pulmonary hypertension. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Additional CRLR Products

Array NBP3-28437APC

Research Areas for CRLR Antibody (NBP3-28437APC)

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Bioinformatics

Gene Symbol CALCRL