ADAMTS13 Antibody

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates at least four transcript variants encoding different isoforms.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 5 of 5.

Publications using NB100-584	Applications	Species
Hunt RC, Geetha S, Allen CE et al. Detection of a secreted metalloprotease within the nuclei of liver cells. Mol Biosyst 2011-06-01 [PMID: 21479334]
Chung MC, Popova TG, Jorgensen SC et al. Degradation of circulating von Willebrand factor and its regulator ADAMTS13 implicates secreted Bacillus anthracis metalloproteases in anthrax consumptive coagulopathy. J Biol Chem 2008-04-01 [PMID: 18263586]
Tao Z, Peng Y, Nolasco L et al. Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions. Blood 2005-12-01 [PMID: 16141351]
Dong JF. Cleavage of ultra-large von Willebrand factor by ADAMTS-13 under flow conditions. J Thromb Haemost 2005-08-01 [PMID: 16102037]
Tao Z, Wang Y, Choi H et al. Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow. Blood 2005-07-01 [PMID: 15774619]

Array NB100-584

• ADAMTS13 Antibodies
• ADAMTS13 ELISA Kit
• ADAMTS13 Lysate
• ADAMTS13 Proteins
• ADAMTS13 Proteins and Enzymes
• ADAMTS13 ELISAs