NOD2 Products

Description

NOD2 (nucleotide-binding oligomerization domain containing 2) is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB. It also acts as an intracellular receptor for bacterial lipopolysaccharides and contributes to inflammatory bowel disease (IBD) and Crohn's disease.

Bioinformatics

Uniprot	AAI56572.1 Human NP_071445 Human NP_071445 Human NP_071445.1 Human NP_071445.1 Human Q9HC29 Human
Product By Gene ID	64127
Alternate Names	BLAU CARD15caspase recruitment domain protein 15 caspase recruitment domain family, member 15 Caspase recruitment domain-containing protein 15 CDACUG CLR16.3 IBD1NLR family, CARD domain containing 2 Inflammatory bowel disease protein 1 NLRC2 NOD-like receptor C2 nucleotide-binding oligomerization domain 2 nucleotide-binding oligomerization domain containing 2 nucleotide-binding oligomerization domain, leucine rich repeat and CARD domaincontaining 2 nucleotide-binding oligomerization domain-containing protein 2 PSORAS1NOD2B

Research Areas for NOD2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Autophagy
Cancer
Caspases
Cell Biology

Related NOD2 Blog Posts

Check out the latest blog posts on NOD2.

Cluster of Differentiation 3 (CD3) (OKT3 clone) as a Marker of Immune Response Efficiency Our immune system is a powerful defense mechanism against infection, however different variables can cause our immune response to work for or against us.  CD3 (cluster of differentiation 3) is one component of our immune signal response that is co...    Read more.

MHC Class I and the Herpes Simplex Virus MHC molecules (also known as major histocompatibility complex molecules) assist in the presentation of antigens to T cells in order to eradicate foreign pathogens.  These molecules are highly polymorphic, meaning that they exist in multiple varian...    Read more.

Transferrin and the blood brain barrier Transferrin, an iron binding protein that facilitates iron uptake in cells, is an integral part of a mechanism that may introduce antibody therapies to the central nervous system. Currently, the brain’s ability to take in antibody therapies i...    Read more.

Read more.

NOD2 - inflammatory signaling and NFkB activation Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular pattern recognition receptor (PRR) that plays an important role in recognizing bacterial pathogens and initiating an immune response. As a PRR, NOD2 recogniz...    Read more.

Read more NOD2 related blogs.