Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Bv, Pm, Ze
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM]
Bioinformatics
| Uniprot |
Human
|
| Product By Gene ID |
204801 |
| Alternate Names |
- CLR19.6
- NACHT, leucine rich repeat and PYD containing 11
- NALP11NACHT, LRR and PYD domains-containing protein 11
- NLR family, pyrin domain containing 11
- NOD17PYPAF7
- Nucleotide-binding oligomerization domain protein 17
- nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 11
- PAAD- and NACHT-containing protein 10
- PAAD- and NACHT-containing protein 10B
- PAAD-and NACHT domain-containing protein 10
- PAN10FLJ26273
- PYPAF6NACHT, LRR and PYD containing protein 11
- PYRIN-containing APAF1-like protein 6
|
