INSIG-2 Products

Description

The protein encoded by the INSIG2 gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 proteinand this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element bindingproteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPsto the Golgi. (provided by RefSeq)

Bioinformatics

Entrez	51141 Human
Uniprot	AAH22475 Human NM_016133 Human Q9Y5U4 Human
Product By Gene ID	51141
Alternate Names	INSIG2 membrane protein INSIG-2 insulin induced gene 2 insulin induced protein 2 insulin-induced gene 2 protein MGC26273

Related INSIG-2 Blog Posts

Check out the latest blog posts on INSIG-2.

SREBP: Gatekeeper of Cholesterol Homeostasis SREBP1 (sterol-regulatory-element-binding protein 2) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. It regulates sterol and cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g. ...    Read more.

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