EphB4 Products

Description

EphB4, also known as Htk, Myk1, Tyro11, and Mdk2, is a member of the Eph receptor family, which binds of the ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region contains juxtamembrane motif with two tyrosines, which are the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the carboxyl terminus, which includes one conserved tyrosine. Ligand recognition and binding leads to activation of intrinsic kinase activity. Only membrane-bound or Fc-clustered ligands have been shown to activate the receptor in vitro. Soluble monomeric ligands can bind the receptor, but do not induce receptor autophosphorylation and activation. The Eph receptors and ephrin ligands display reciprocal expression in vivo. Developing and adult neural tissue express nearly all of the Eph receptors and ephrin ligands.Ephs and ephrins play a significant role in angiogenesis.

Bioinformatics

Entrez	13846 Mouse 2050 Human
Uniprot	AAH52804 Human AAH52804.1 Human NM_004444 Human NP_004435.3 Human P54760 Human
Product By Gene ID	2050
Alternate Names	EC 2.7.10 EC 2.7.10.1 EPH receptor B4 EphB4 ephrin type-B receptor 4 hepatoma transmembrane kinase HTKephrin receptor EphB4 MYK1 soluble EPHB4 variant 1 soluble EPHB4 variant 2 soluble EPHB4 variant 3 TYRO11 Tyro11 Tyrosine-protein kinase receptor HTK Tyrosine-protein kinase TYRO11

Research Areas for EphB4

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Protein Kinase

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