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Tubulointerstitial Nephritis: Disease Bioinformatics

Research of Tubulointerstitial Nephritis has been linked to Nephritis, Nephritis, Interstitial, Kidney Diseases, Kidney Failure, Glomerulonephritis. The study of Tubulointerstitial Nephritis has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Tubulointerstitial Nephritis include Pathogenesis, Excretion, Glomerular Filtration, Hypersensitivity, Immune Response. These pathways complement our catalog of research reagents for the study of Tubulointerstitial Nephritis including antibodies and ELISA kits against TAMM-HORSFALL PROTEIN, ALB, C3, CD4, CD8A.

Top Research Reagents

We have 7193 products for the study of Tubulointerstitial Nephritis that can be applied to Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

IL-6 [HRP]

D6050B

Species Human

785 Publications

CD8 Antibody (53-6.7) - BSA Free

NBP1-49045

Rat Monoclonal
Species Mouse, Rat
Applications Flow, ICC/IF, IHC

3 Reviews

28 Publications

IL-6 [HRP]

D6050B

Species Human

785 Publications

CD8 Antibody (53-6.7) - BSA Free

NBP1-49045

Rat Monoclonal
Species Mouse, Rat
Applications Flow, ICC/IF, IHC

3 Reviews

28 Publications

Fibronectin Antibody - BSA Free

NBP1-91258

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

11 Reviews

56 Publications

MUC5AC Antibody (45M1)

NBP2-15196

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, DB, Flow

5 Reviews

28 Publications

Myeloperoxidase/MPO Antibody [Unconjugated]

AF3667

Western blot shows lysates of HL-60 human acute promyelocytic leukemia cell line, human neutrophil cells, and mouse spleen tissue. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human/Mouse Myeloperoxidase/MPO Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3667) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (<a class=

Myeloperoxidase/MPO was detected in immersion fixed mouse splenocytes using Goat Anti-Human/Mouse Myeloperoxidase/MPO Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3667) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&#8482; 557-conjugated Anti-Goat IgG Secondary Antibody (red; <a class=

Goat Polyclonal
Species Human, Mouse
Applications WB, Simple Western, IHC

3 Reviews

172 Publications

Uromodulin Antibody [Unconjugated]

AF5175

Western blot shows lysates of mouse kidney tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Mouse Uromodulin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5175) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (<a class=

Uromodulin was detected in immersion fixed frozen sections of mouse kidney using Sheep Anti-Mouse Uromodulin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5175) at 10 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights&#8482; 557-conjugated Anti-Sheep IgG Secondary Antibody (red; <a class=

Sheep Polyclonal
Species Mouse
Applications WB, Simple Western, IHC

8 Publications

ICAM-1/CD54 Antibody [Unconjugated]

AF796

ICAM-1/CD54 was detected in perfusion fixed frozen sections of mouse testis using Goat Anti-Mouse ICAM-1/CD54 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF796) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <a class=

Increased stress kinase signaling and JNK pathway-dependent cytokine and chemokine production by primary keratinocytes lacking BRAF and RAF1.(A) Reduced ERK phosphorylation and increased JNK/p38 activation in primary delta / delta ep2 keratinocytes stimulated with EGF and/or TNF alpha and IL1 beta for 15 min. (B) Increased cytokine and chemokine production in primary delta / delta ep2 keratinocytes treated with EGF, TNF alpha and IL1 beta for 24 hr. Cytokine and chemokine production was determined by multiplex analysis, except for TSLP which was quantified by ELISA. Data represent mean ± SEM of 3–5 biological replicates. (C–D) Cells were pretreated with D-JNKI1 inhibitors prior to stimulation with EGF, TNF alpha and IL1 beta for 15 min (C) or 24 hr (D). Data represent the mean ± SEM of technical replicates (n = 3). (E–F) Effect of shRNA-mediated Mlk3 silencing on ERK and JNK phosphorylation and ICAM1 expression (E; stimulation with EGF, TNF alpha and IL1 beta for 15 min) and on the expression of Ccl2 and Tslp mRNA (F; stimulation with EGF, TNF alpha and IL1 beta for 24 hr) by F/F2 and delta / delta ep2 keratinocytes. shRen, shRNA targeting Renilla, used as a control; sh1 and sh2, targeting Mlk3, binding sites nucleotide 2266–2285 and 2383–2402, respectively. The shRNAs were encoded by lentiviral vectors coexpressing GFP. GFP immunoblots are shown to confirm similar levels of infection in all samples. Data represent mean ± SEM of 4 biological replicates. Each keratinocyte culture represents a pool of three mice. Immunoblots are representative of three independent experiments. p1 = 0.041, p2 = 0.040, p3 = 1.89E-4, p4 = 0.018, p5 = 0.046, p6 = 0.020, p7 = 0.008, p8 = 0.016, p9 = 0.001, p10 = 0.018, p11 = 3.23E-4, p12 = 1.47E-4, p13 = 0.007, p14 = 0.03, p15 = 0.035, p16 = 0.023 and p17 = 0.046.DOI:https://dx.doi.org/10.7554/eLife.14012.018Compound knockdown (KD2) of BRAF and RAF1 induce the expression of inflammation markers by HaCat cells in a MLK3/JNK-dependent manner.(A) Reduced ERK and increased JNK/p38 activation in BRAF and RAF1 knockdown (KD2) HaCat cells stimulated with EGF, TNF alpha and IL1 beta for 15 min. (B) D-JNKI1 reduces ICAM1 and CCL2 (n = 4) expression in KD2 cells treated with TNF alpha . (C) MEKi induces ICAM1 and CCL2 (n = 3) expression in RAF1KD cells treated with TNF alpha . In (B–C), ICAM1 expression was measured after a 3 hr, CCL2 expression after a 24 hr treatment with TNF alpha . (D) Effect of MLK3 silencing on ERK and JNK phosphorylation in WT and KD2 cells stimulated as in (A). MLK3 was silenced using a pool of oligonucleotides targeting the following regions: 686–704; 1489–1507; 2122–2138; and 2348–2366. MLK3 KD cells stimulated as in (B–C) show a decrease in JNK activation, ICAM1 and CCL2 (n = 7) expression. Immunoblots are representative of three independent experiments. qPCR data represent mean ± SEM of three independent experiments run in duplicates (p1 = 4.62E-4, p2 = 0.013, p3 = 0.050, p4 = 8.60E-8, p5 = 0.050, p6 = 0.001, p7 = 0.001 and p8 = 0.012).DOI:https://dx.doi.org/10.7554/eLife.14012.019 Image collected and cropped by CiteAb from the following publication (https://elifesciences.org/articles/14012), licensed under a CC-BY license. Not internally tested by R&D Systems.

Goat Polyclonal
Species Mouse
Applications WB, IHC, AdBlk

6 Reviews

89 Publications

TIN-Ag Antibody

AF6797

Western blot shows lysates of human kidney (cortex and medulla) tissue. PVDF Membrane was probed with 1 µg/mL of Sheep Anti-Human TIN-Ag Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6797) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <a class=

Sheep Polyclonal
Species Human
Applications WB

TINAGL1 Antibody (812417)

MAB7185

Western blot shows lysates of human placenta tissue and human kidney tissue. PVDF membrane was probed with 0.5 µg/mL of Mouse Anti-Human TINAGL1 Monoclonal Antibody (Catalog # MAB7185) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <a class=

Simple Western lane view shows lysates of human placenta tissue, loaded at 0.5&nbsp;mg/mL. A specific band was detected for TINAGL1 at approximately 59&nbsp;kDa (as indicated) using 5&nbsp;µg/mL of Mouse Anti-Human TINAGL1 Monoclonal Antibody (Catalog # MAB7185). This experiment was conducted&nbsp;under&nbsp;reducing&nbsp;conditions and using the 12-230 kDa separation system. </P><P>Non-specific interaction with the 230 kDa Simple Western standard may be seen with this antibody.

Mouse Monoclonal
Species Human
Applications WB, Simple Western

Complement Component C3d Antibody [Unconjugated]

AF2655

Complement Component&nbsp;C3d was detected in perfusion fixed frozen sections of mouse kidney using Goat Anti-Mouse Complement Component&nbsp;C3d Antigen Affinity-purified Polyclonal Antibody (Catalog&nbsp;# AF2655) overnight at 4&nbsp;°C. Tissue was stained using the NorthernLights&#8482; 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog&nbsp;# <A class=NoLineLink href=

Complement Component&nbsp;C3d was detected in perfusion fixed paraffin-embedded sections of rat kidney using Goat Anti-Mouse Complement Component&nbsp;C3d Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2655) at 3&nbsp;µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte&#8482; HRP Polymer Antibody (Catalog&nbsp;# <a class=

Goat Polyclonal
Species Mouse, Rat
Applications WB, IHC

61 Publications

Albumin Antibody (188835) [Unconjugated] - Serum

MAB1455

Western blot shows lysate of human liver tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human Serum Albumin Monoclonal Antibody (Catalog # MAB1455) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <a class=

Albumin was detected in immersion fixed BG01V human embryonic stem cells differentiated to hepatocytes using Mouse Anti-Human Serum Albumin Monoclonal Antibody (Catalog # MAB1455) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&#8482; 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # <a class=

Mouse Monoclonal
Species Human
Applications WB, Simple Western, IHC

3 Reviews

56 Publications

CCL2/JE/MCP-1 [HRP]

DCP00

Species Human
Applications ELISA

258 Publications

TNF-alpha [Unconjugated]

210-TA

Species Human
Applications BA

3 Reviews

824 Publications

CD4 Antibody - BSA Free

NBP1-19371

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, Flow

9 Reviews

52 Publications

TIN2 Antibody - BSA Free

NBP2-55709

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF

2 Publications

RAPGEF5 Antibody - BSA Free

NBP2-57362

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF

p14ARF/CDKN2A Antibody - BSA Free

NB200-111

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Flow, ICC/IF

2 Reviews

18 Publications

Nephronophthisis Antibody - Azide and BSA Free

NBP2-94059

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

Related Genes

Tubulointerstitial Nephritis has been researched against:

Related Pathways

Tubulointerstitial Nephritis has been linked to:

Related Diseases

Tubulointerstitial Nephritis has been studied in relation to diseases such as:

Related PTMs

Tubulointerstitial Nephritis has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Tubulointerstitial Nephritis is also known as Nephritis, Tubulointerstitial, Tubulo-interstitial Nephritis, Tubulointerstitial Nephritides.